FBH1
Gene Ontology Biological Process
- DNA duplex unwinding [IDA]
- DNA recombination [IGI]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA]
- double-strand break repair via homologous recombination [IGI]
- protein ubiquitination [IDA]
- regulation of DNA recombination [IGI]
- regulation of strand invasion [IDA]
- replication fork processing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RQH1
Gene Ontology Biological Process
- DNA duplex unwinding [IDA]
- cellular response to DNA damage stimulus [IMP]
- double-strand break repair via homologous recombination [IGI]
- intra-S DNA damage checkpoint [IDA]
- maintenance of rDNA [IMP]
- mitotic DNA replication DNA duplex unwinding [ISO]
- negative regulation of mitotic recombination [IMP]
- postreplication repair [IMP]
- recombinational repair [IGI]
- regulation of mitotic recombination involved in replication fork processing [IMP]
- replication fork processing at rDNA locus [IGI]
- resolution of mitotic recombination intermediates [IMP]
- telomere maintenance [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The F-Box DNA helicase Fbh1 prevents Rhp51-dependent recombination without mediator proteins.
A key step in homologous recombination is the loading of Rad51 onto single-stranded DNA to form a nucleoprotein filament that promotes homologous DNA pairing and strand exchange. Mediator proteins, such as Rad52 and Rad55-Rad57, are thought to aid filament assembly by overcoming an inhibitory effect of the single-stranded-DNA-binding protein replication protein A. Here we show that mediator proteins are also ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- data not shown
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RQH1 FBH1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | High | - | PomBase | - | |
| FBH1 RQH1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 248123 |
Curated By
- BioGRID