CLR3
Gene Ontology Biological Process
- chromatin silencing at centromere [IMP]
- chromatin silencing at rDNA [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [IMP]
- histone H3 deacetylation [IMP]
- histone deacetylation [IDA, IMP]
- maintenance of chromatin silencing at silent mating-type cassette [NAS]
- negative regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- nucleosome positioning [IMP]
- regulation of histone methylation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DCR1
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis [IDA]
- RNA processing [IDA]
- cellular protein localization [IMP]
- chromatin silencing by small RNA [TAS]
- co-transcriptional gene silencing by RNA interference machinery [IMP]
- establishment of chromatin silencing at silent mating-type cassette [IMP]
- production of siRNA involved in RNA interference [IDA]
- regulation of chromatin silencing at centromere [IMP]
- regulation of histone H3-K9 methylation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
RNAi and heterochromatin repress centromeric meiotic recombination.
During meiosis, the formation of viable haploid gametes from diploid precursors requires that each homologous chromosome pair be properly segregated to produce an exact haploid set of chromosomes. Genetic recombination, which provides a physical connection between homologous chromosomes, is essential in most species for proper homologue segregation. Nevertheless, recombination is repressed specifically in and around the centromeres of chromosomes, apparently ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: mitotic recombination (APO:0000225)
Additional Notes
- double mutant shows increased recombination in centromeric regions
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CLR3 DCR1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -2.7076 | BioGRID | 526861 | |
| DCR1 CLR3 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 862514 |
Curated By
- BioGRID