BAIT
UBE2E1
UBCH6
ubiquitin-conjugating enzyme E2E 1
GO Process (14)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- ISG15-protein conjugation [IDA]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- cytokine-mediated signaling pathway [TAS]
- histone H2B ubiquitination [IDA]
- histone monoubiquitination [IDA]
- mitotic cell cycle [TAS]
- mitotic spindle assembly checkpoint [TAS]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- protein K48-linked ubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RNF165
ARKL2, RNF111L2
ring finger protein 165
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.
Covalent attachment of ubiquitin to substrates is crucial to protein degradation, transcription regulation and cell signalling. Highly specific interactions between ubiquitin-conjugating enzymes (E2) and ubiquitin protein E3 ligases fulfil essential roles in this process. We performed a global yeast-two hybrid screen to study the specificity of interactions between catalytic domains of the 35 human E2s with 250 RING-type E3s. Our ... [more]
Mol. Syst. Biol. Aug. 20, 2009; 5(0);295 [Pubmed: 19690564]
Throughput
- High Throughput
Curated By
- BioGRID