RAD6
Gene Ontology Biological Process
- DNA-templated transcription, termination [IMP]
- ER-associated ubiquitin-dependent protein catabolic process [IGI]
- chromatin silencing at telomere [IMP]
- double-strand break repair via homologous recombination [IGI]
- error-free postreplication DNA repair [IGI]
- error-free translesion synthesis [IGI]
- error-prone translesion synthesis [IGI]
- histone monoubiquitination [IMP]
- meiotic DNA double-strand break formation [IMP]
- mitotic G1 DNA damage checkpoint [IMP]
- protein monoubiquitination [IMP]
- protein polyubiquitination [IMP]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- regulation of dipeptide transport [IMP]
- telomere maintenance via recombination [IGI]
- transcription from RNA polymerase II promoter [IPI]
- ubiquitin-dependent protein catabolic process via the N-end rule pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAD9
Gene Ontology Biological Process
Gene Ontology Molecular Function
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
The RAD6/BRE1 histone modification pathway in Saccharomyces confers radiation resistance through a RAD51-dependent process that is independent of RAD18.
We examine ionizing radiation (IR) sensitivity and epistasis relationships of several Saccharomyces mutants affecting post-translational modifications of histones H2B and H3. Mutants bre1Delta, lge1Delta, and rtf1Delta, defective in histone H2B lysine 123 ubiquitination, show IR sensitivity equivalent to that of the dot1Delta mutant that we reported on earlier, consistent with published findings that Dot1p requires H2B K123 ubiquitination to fully ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: x ray resistance (APO:0000086)
- phenotype: vegetative growth (APO:0000106)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
RAD6 RAD9 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 518430 | |
RAD9 RAD6 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | High | - | BioGRID | 457442 |
Curated By
- BioGRID