P53
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator [TAS]
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IBA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- apoptotic process [IMP, TAS]
- cell death [IMP]
- cellular response to DNA damage stimulus [IDA, IMP]
- cellular response to UV [IBA]
- cellular response to gamma radiation [IMP]
- cellular response to starvation [IMP]
- determination of adult lifespan [IMP]
- ectopic germ cell programmed cell death [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP, TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP, TAS]
- mitotic G1 DNA damage checkpoint [IBA]
- negative regulation of photoreceptor cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IBA]
- neuroblast differentiation [IMP]
- neuroblast proliferation [IMP]
- oogenesis [IGI]
- positive regulation of cell cycle [IGI]
- positive regulation of cellular response to X-ray [IMP]
- positive regulation of macroautophagy [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IBA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- reciprocal meiotic recombination [IMP]
- regulation of DNA repair [IMP]
- regulation of cell proliferation [IMP]
- regulation of neuron apoptotic process [IBA]
- regulation of organ growth [IMP]
- regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of transcription from RNA polymerase II promoter in response to DNA damage [IMP]
- response to UV [IMP]
- response to X-ray [IBA]
- response to gamma radiation [IBA]
- response to ionizing radiation [IMP]
- response to radiation [IMP, TAS]
- response to starvation [IMP]
- tissue regeneration [IMP]
Gene Ontology Molecular Function- DNA binding [NAS]
- chromatin binding [IBA]
- core promoter binding [IDA]
- damaged DNA binding [IBA]
- double-stranded DNA binding [IBA]
- p53 binding [IBA]
- protein binding [IPI]
- sequence-specific DNA binding [IBA]
- sequence-specific DNA binding transcription factor activity [IBA, NAS]
- transcription factor binding [IPI]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase binding [IPI]
- DNA binding [NAS]
- chromatin binding [IBA]
- core promoter binding [IDA]
- damaged DNA binding [IBA]
- double-stranded DNA binding [IBA]
- p53 binding [IBA]
- protein binding [IPI]
- sequence-specific DNA binding [IBA]
- sequence-specific DNA binding transcription factor activity [IBA, NAS]
- transcription factor binding [IPI]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
MMP2
Gene Ontology Biological Process
- activation of innate immune response [IDA]
- basement membrane disassembly [IMP]
- basement membrane organization [IMP]
- imaginal disc eversion [IMP]
- imaginal disc fusion, thorax closure [IMP]
- lateral inhibition [IMP]
- negative regulation of fibroblast growth factor receptor signaling pathway [IDA]
- oogenesis [IMP]
- open tracheal system development [IMP]
- tracheal outgrowth, open tracheal system [IMP]
- tracheal pit formation in open tracheal system [IMP]
- wound healing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network.
The genome of the fruitfly Drosophila melanogaster contains a single p53-like protein, phylogenetically related to the ancestor of the mammalian p53 family of tumor suppressors. We reasoned that a comprehensive map of the protein interaction profile of Drosophila p53 (Dmp53) might help identify conserved interactions of the entire p53 family in man. Using a genome-scale in vitro expression cloning approach, ... [more]
Throughput
- High Throughput
Curated By
- BioGRID