BAIT

GLC3

GHA1, 1,4-alpha-glucan branching enzyme, L000000705, YEL011W
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
GO Process (1)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

TPS1

BYP1, CIF1, FDP1, GGS1, GLC6, TSS1, alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1, L000002330, YBR126C
Synthase subunit of trehalose-6-P synthase/phosphatase complex; synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
Saccharomyces cerevisiae (S288c)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Trehalose is a key determinant of the quiescent metabolic state that fuels cell cycle progression upon return to growth.

Shi L, Sutter BM, Ye X, Tu BP

When conditions are unfavorable, virtually all living cells have the capability of entering a resting state termed quiescence or G0. Many aspects of the quiescence program as well as the mechanisms governing the entry and exit from quiescence remain poorly understood. Previous studies using the budding yeast Saccharomyces cerevisiae have shown that upon entry into stationary phase, a quiescent cell ... [more]

Mol. Biol. Cell Jun. 15, 2010; 21(12);1982-90 [Pubmed: 20427572]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: cellular morphology (APO:0000050)

Additional Notes

  • double mutants show reduced cell density in response to quiescence

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
GLC3 TPS1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.1589BioGRID
373763
GLC3 TPS1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.1761BioGRID
2104531

Curated By

  • BioGRID