BAIT
UBE2V2
DDVIT1, DDVit-1, EDAF-1, EDPF-1, EDPF1, MMS2, UEV-2, UEV2
ubiquitin-conjugating enzyme E2 variant 2
GO Process (7)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
XIAP
API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3, RP1-315G1.5
X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
GO Process (17)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular response to DNA damage stimulus [IEP]
- copper ion homeostasis [TAS]
- inhibition of cysteine-type endopeptidase activity involved in apoptotic process [IBA]
- intrinsic apoptotic signaling pathway [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of protein linear polyubiquitination [IDA]
- positive regulation of protein ubiquitination [IDA]
- protein ubiquitination [IDA]
- regulation of BMP signaling pathway [TAS]
- regulation of cell proliferation [TAS]
- regulation of inflammatory response [TAS]
- regulation of innate immune response [TAS]
- regulation of nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- spindle assembly involved in mitosis [IBA]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.
In eukaryotic cells the stability and function of many proteins are regulated by the addition of ubiquitin or ubiquitin-like peptides. This process is dependent upon the sequential action of an E1-activating enzyme, an E2-conjugating enzyme, and an E3 ligase. Different combinations of these proteins confer substrate specificity and the form of protein modification. However, combinatorial preferences within ubiquitination networks remain ... [more]
Genome Res. Oct. 01, 2009; 19(10);1905-11 [Pubmed: 19549727]
Quantitative Score
- 4.0 [Confidence Score]
Throughput
- High Throughput
Curated By
- BioGRID