BAIT

UBE2K

E2-25K, HIP2, HYPG, LIG, UBC1
ubiquitin-conjugating enzyme E2K
Alzheimer's Disease Project
UPS Project
Homo sapiens
PREY

LRSAM1

CMT2P, RIFLE, TAL, UNQ6496/PRO21356
leucine rich repeat and sterile alpha motif containing 1
Autophagy Project
UPS Project
GO Process (6)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.

Markson G, Kiel C, Hyde R, Brown S, Charalabous P, Bremm A, Semple J, Woodsmith J, Duley S, Salehi-Ashtiani K, Vidal M, Komander D, Serrano L, Lehner P, Sanderson CM

In eukaryotic cells the stability and function of many proteins are regulated by the addition of ubiquitin or ubiquitin-like peptides. This process is dependent upon the sequential action of an E1-activating enzyme, an E2-conjugating enzyme, and an E3 ligase. Different combinations of these proteins confer substrate specificity and the form of protein modification. However, combinatorial preferences within ubiquitination networks remain ... [more]

Genome Res. Oct. 01, 2009; 19(10);1905-11 [Pubmed: 19549727]

Quantitative Score

  • 4.0 [Confidence Score]

Throughput

  • High Throughput

Curated By

  • BioGRID