BAIT
UBE2O
E2-230K
ubiquitin-conjugating enzyme E2O
GO Process (4)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
TRIM27
RFP, RNF76, DAAP-182E11.3
tripartite motif containing 27
GO Process (18)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- Arp2/3 complex-mediated actin nucleation [IDA]
- cell proliferation [TAS]
- innate immune response [IDA]
- interferon-gamma secretion [IMP]
- negative regulation of adaptive immune response [IMP]
- negative regulation of calcium ion import [IMP]
- negative regulation of gene expression, epigenetic [IDA]
- negative regulation of interleukin-2 secretion [IMP]
- negative regulation of protein kinase activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of tumor necrosis factor production [IMP]
- negative regulation of viral transcription [IDA]
- peptidyl-tyrosine phosphorylation [TAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- protein K63-linked ubiquitination [IMP]
- protein trimerization [IDA]
- retrograde transport, endosome to Golgi [IDA]
- spermatogenesis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.
In eukaryotic cells the stability and function of many proteins are regulated by the addition of ubiquitin or ubiquitin-like peptides. This process is dependent upon the sequential action of an E1-activating enzyme, an E2-conjugating enzyme, and an E3 ligase. Different combinations of these proteins confer substrate specificity and the form of protein modification. However, combinatorial preferences within ubiquitination networks remain ... [more]
Genome Res. Oct. 01, 2009; 19(10);1905-11 [Pubmed: 19549727]
Quantitative Score
- 4.0 [Confidence Score]
Throughput
- High Throughput
Curated By
- BioGRID