BAIT
UBE2H
E2-20K, GID3, UBC8, UBCH, UBCH2
ubiquitin-conjugating enzyme E2H
GO Process (3)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
RNF6
RP11-380N8.5
ring finger protein (C3H2C3 type) 6
GO Process (8)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- negative regulation of axon extension [ISS]
- positive regulation of transcription, DNA-templated [IMP]
- protein K27-linked ubiquitination [IDA]
- protein K48-linked ubiquitination [ISS]
- protein K6-linked ubiquitination [IDA]
- regulation of androgen receptor signaling pathway [IMP]
- regulation of transcription, DNA-templated [IMP]
- ubiquitin-dependent protein catabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.
In eukaryotic cells the stability and function of many proteins are regulated by the addition of ubiquitin or ubiquitin-like peptides. This process is dependent upon the sequential action of an E1-activating enzyme, an E2-conjugating enzyme, and an E3 ligase. Different combinations of these proteins confer substrate specificity and the form of protein modification. However, combinatorial preferences within ubiquitination networks remain ... [more]
Genome Res. Oct. 01, 2009; 19(10);1905-11 [Pubmed: 19549727]
Quantitative Score
- 4.0 [Confidence Score]
Throughput
- High Throughput
Curated By
- BioGRID