BAIT
SCK2
SPAC22E12.14c
serine/threonine protein kinase Sck2
GO Process (4)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
ATF1
gad7, mts1, sss1, SPNCRNA.353, SPNG1409, SPBC29B5.01
transcription factor, Atf-CREB family Atf1
GO Process (15)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- activation of reciprocal meiotic recombination [IMP]
- cellular response to nitrogen starvation [IMP]
- cellular response to starvation [IMP]
- mRNA export from nucleus in response to heat stress [IMP]
- negative regulation of G1/S transition of mitotic cell cycle by positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation [IMP]
- negative regulation of antisense RNA transcription [IMP]
- negative regulation of reciprocal meiotic recombination [IMP]
- negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IMP]
- nucleosome positioning [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of cAMP-mediated signaling [IMP]
- regulation of histone acetylation by regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of histone methylation by regulation of transcription from RNA polymerase II promoter [IMP]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- RNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- recombination hotspot binding [IDA]
- sequence-specific DNA binding [IDA]
- RNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- recombination hotspot binding [IDA]
- sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Living on the edge: stress and activation of stress responses promote lifespan extension.
Oxidative stress constitutes the basis of physio-pathological situations such as neurodegenerative diseases and aging. However, sublethal exposure to toxic molecules such as reactive oxygen species can induce cellular responses that result in stress fitness. Studies in Schizosaccharomyces pombe have recently showed that the Sty1 MAP kinase, known to be activated by hydrogen peroxide and other cellular stressors, plays a pivotal ... [more]
Aging (Albany NY) Apr. 01, 2010; 2(4);231-7 [Pubmed: 20453258]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID