A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage.

Dolan WP, Le AH, Schmidt H, Yuan JP, Green M, Forsburg SL

Genome stability in fission yeast requires the conserved S-phase kinase Hsk1 (Cdc7) and its partner Dfp1 (Dbf4). In addition to their established function in the initiation of DNA replication, we show that these proteins are important in maintaining genome integrity later in S phase and G2. hsk1 cells suffer increased rates of mitotic recombination and require recombination proteins for survival. ... [more]

Genetics May. 01, 2010; 185(1);39-53 [Pubmed: 20176980]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
SWI1 RAD21	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Ansbach AB (2008)	Low	-	BioGRID	300775

Curated By

BioGRID

Interaction Summary

SWI1

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA binding [IDA]chromatin binding [IDA]protein binding [IPI]

Gene Ontology Cellular Component

RAD21