BAIT
HRS
CG2903, DmHRS, Dmel\CG2903, HRS-2, Vps27, dHrs, l(2)23AB5, l(2)23Ad, l(2)23Ad(Hrs), Dmel_CG2903
Hepatocyte growth factor regulated tyrosine kinase substrate
GO Process (20)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
- border follicle cell migration [IMP]
- endocytosis [IMP, NAS]
- endosomal transport [IMP, ISS, TAS]
- endosome to lysosome transport [TAS]
- endosome transport via multivesicular body sorting pathway [IMP]
- exocytosis [TAS]
- membrane protein proteolysis [IMP]
- negative regulation of epidermal growth factor receptor signaling pathway [IMP, NAS]
- negative regulation of protein phosphorylation [IDA]
- neurotransmitter secretion [NAS]
- positive regulation of Toll signaling pathway [IMP]
- positive regulation of fibroblast growth factor receptor signaling pathway [IMP]
- positive regulation of protein ubiquitination [IMP]
- regulation of Notch signaling pathway [IGI]
- regulation of cell cycle [IGI]
- regulation of epithelial cell migration, open tracheal system [IMP]
- synaptic vesicle exocytosis [ISS]
- synaptic vesicle priming [NAS]
- torso signaling pathway [IMP, NAS]
- vesicle organization [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
PREY
STAM
CG6521, Dmel\CG6521, Dstam, Stam1, Dmel_CG6521
Signal transducing adaptor molecule
GO Process (11)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- JAK-STAT cascade [NAS]
- endosomal transport [IMP, ISS]
- epithelial cell migration, open tracheal system [IMP]
- negative regulation of epidermal growth factor receptor signaling pathway [IMP]
- neurotransmitter secretion [NAS]
- positive regulation of fibroblast growth factor receptor signaling pathway [IMP]
- regulation of JAK-STAT cascade [TAS]
- regulation of cell cycle [IGI]
- regulation of epithelial cell migration, open tracheal system [IMP]
- synaptic vesicle endocytosis [NAS]
- wound healing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interaction mapping: a Drosophila case study.
The Drosophila (fruit fly) model system has been instrumental in our current understanding of human biology, development, and diseases. Here, we used a high-throughput yeast two-hybrid (Y2H)-based technology to screen 102 bait proteins from Drosophila melanogaster, most of them orthologous to human cancer-related and/or signaling proteins, against high-complexity fly cDNA libraries. More than 2300 protein-protein interactions (PPI) were identified, of ... [more]
Genome Res. Mar. 01, 2005; 15(3);376-84 [Pubmed: 15710747]
Throughput
- High Throughput
Additional Notes
- Predicted Biological Score:A
Related interactions
Curated By
- BioGRID