BAIT
RPR
CG4319, Dmel\CG4319, anon-WO0162936.19, rp, Dmel_CG4319
reaper
GO Process (20)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- apoptotic process [IDA, IEP, IMP, NAS, TAS]
- apoptotic signaling pathway [IGI, IMP]
- cell death [IMP]
- cellular response to gamma radiation [IMP]
- cellular response to ionizing radiation [IDA]
- ecdysone-mediated induction of salivary gland cell autophagic cell death [IEP]
- imaginal disc-derived male genitalia morphogenesis [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- intrinsic apoptotic signaling pathway in response to osmotic stress [TAS]
- larval central nervous system remodeling [TAS]
- larval midgut cell programmed cell death [IGI, NAS]
- negative regulation of neuron apoptotic process [IMP]
- nurse cell apoptotic process [TAS]
- positive regulation of cysteine-type endopeptidase activity [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [IDA]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IGI]
- programmed cell death [IMP, TAS]
- regulation of protein catabolic process [IDA]
- salivary gland cell autophagic cell death [IGI, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
PREY
HSC70-3
A4V4C4_DROME, BiP, CG1579, CG4147, Dmel\CG4147, GRP78, HSC-70, HSC3, HSC70, HSP7C_DROME, Hsc-3, Hsc-70-3, Hsc3p, Hsp-c3, anon-WO0138581.7, dBiP, dhsc70, dmHsc72, hsc72, l(1)G0102, l(1)G0111, l(1)G0292, l(1)G0341, l(1)G0407, l(1)G0466, Dmel_CG4147
Heat shock 70-kDa protein cognate 3
GO Process (4)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interaction mapping: a Drosophila case study.
The Drosophila (fruit fly) model system has been instrumental in our current understanding of human biology, development, and diseases. Here, we used a high-throughput yeast two-hybrid (Y2H)-based technology to screen 102 bait proteins from Drosophila melanogaster, most of them orthologous to human cancer-related and/or signaling proteins, against high-complexity fly cDNA libraries. More than 2300 protein-protein interactions (PPI) were identified, of ... [more]
Genome Res. Mar. 01, 2005; 15(3);376-84 [Pubmed: 15710747]
Throughput
- High Throughput
Additional Notes
- Predicted Biological Score:B
Curated By
- BioGRID