BAIT
CI
CG2125, CID, Ce, Ci/GLI, Ci155, Ci[D], Dmel\CG2125, Gli, Siah, ci-D, l(4)102ABc, l(4)13, l(4)17, Dmel_CG2125
cubitus interruptus
GO Process (21)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- blastoderm segmentation [TAS]
- cuticle pattern formation [IMP]
- dendrite morphogenesis [IMP]
- epidermis development [IMP]
- eye morphogenesis [IMP]
- genital disc anterior/posterior pattern formation [IEP]
- heart formation [IMP]
- labial disc development [IMP]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- neuron development [IMP]
- oogenesis [IEP]
- ovarian follicle cell development [TAS]
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of epithelial cell differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, TAS]
- regulation of mitotic cell cycle [IMP]
- regulation of transcription, DNA-templated [TAS]
- segment polarity determination [IMP]
- smoothened signaling pathway [IEP, IMP, NAS, TAS]
- spiracle morphogenesis, open tracheal system [IMP]
- wing disc anterior/posterior pattern formation [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS, TAS]
- transcription regulatory region DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS, TAS]
- transcription regulatory region DNA binding [IDA]
Drosophila melanogaster
PREY
BOTV
BcDNA:LD21192, CG15110, DEXT3, DEXTL3, Dmel\CG15110, Extl3, Dmel_CG15110
brother of tout-velu
GO Process (8)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- N-acetylglucosamine metabolic process [ISS]
- Wnt signaling pathway [IMP]
- decapentaplegic signaling pathway [IMP]
- glycosaminoglycan biosynthetic process [IMP]
- heparan sulfate proteoglycan biosynthetic process [IDA, NAS]
- heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [IMP, NAS]
- segment polarity determination [NAS]
- smoothened signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interaction mapping: a Drosophila case study.
The Drosophila (fruit fly) model system has been instrumental in our current understanding of human biology, development, and diseases. Here, we used a high-throughput yeast two-hybrid (Y2H)-based technology to screen 102 bait proteins from Drosophila melanogaster, most of them orthologous to human cancer-related and/or signaling proteins, against high-complexity fly cDNA libraries. More than 2300 protein-protein interactions (PPI) were identified, of ... [more]
Genome Res. Mar. 01, 2005; 15(3);376-84 [Pubmed: 15710747]
Throughput
- High Throughput
Additional Notes
- Predicted Biological Score:D
Curated By
- BioGRID