BAIT
RGL
CG8865, DRgl, Dmel\CG8865, RalGDS, RasGDS, Dmel_CG8865
Ral guanine nucleotide dissociation stimulator-like ortholog (M. musculus)
GO Process (2)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Drosophila melanogaster
PREY
FOXO
3143, Afx, CG3143, Dfoxo, DmQ95V5, Dmel\CG3143, FKHR, Q95V55, anon-WO0118547.374, fd88A, Dmel_CG3143
forkhead box, sub-group O
GO Process (42)
GO Function (10)
GO Component (4)
Gene Ontology Biological Process
- cAMP biosynthetic process [IDA, IMP]
- cellular response to DNA damage stimulus [IMP]
- cellular response to amino acid starvation [IDA]
- cellular response to oxidative stress [IMP]
- cellular response to starvation [IMP]
- circadian rhythm [IMP]
- compound eye morphogenesis [IMP]
- dendrite morphogenesis [IMP]
- determination of adult lifespan [IMP]
- female germ-line stem cell maintenance [IMP]
- glycogen metabolic process [IMP]
- imaginal disc-derived wing morphogenesis [IMP]
- insulin receptor signaling pathway [IGI, IPI]
- locomotor rhythm [IGI]
- microtubule bundle formation [IDA]
- myoblast fusion [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of cell size [IMP]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of lipid storage [IDA]
- negative regulation of multicellular organism growth [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IBA]
- negative regulation of transcription, DNA-templated [IMP]
- negative regulation of vulval development [IBA]
- pattern specification process [IBA]
- positive regulation of cellular response to insulin stimulus [IGI]
- positive regulation of feeding behavior [IGI, IMP]
- positive regulation of octopamine signaling pathway [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IBA, IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of activin receptor signaling pathway [IMP]
- regulation of autophagy [IMP]
- regulation of cell growth [IMP]
- regulation of growth [IGI]
- regulation of hemocyte proliferation [IMP]
- regulation of insulin receptor signaling pathway [IGI]
- regulation of macroautophagy [IMP]
- regulation of sequence-specific DNA binding transcription factor activity [IBA]
- response to bacterium [IDA, IMP]
- response to oxidative stress [IMP]
- somatic muscle development [IMP]
- tissue development [IBA]
Gene Ontology Molecular Function- DNA binding [IDA]
- DNA binding, bending [IBA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]
- chromatin DNA binding [IDA]
- double-stranded DNA binding [IBA]
- protein kinase binding [IBA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, IMP, ISS]
- transcription factor binding [IBA]
- DNA binding [IDA]
- DNA binding, bending [IBA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]
- chromatin DNA binding [IDA]
- double-stranded DNA binding [IBA]
- protein kinase binding [IBA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, IMP, ISS]
- transcription factor binding [IBA]
Drosophila melanogaster
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interaction mapping: a Drosophila case study.
The Drosophila (fruit fly) model system has been instrumental in our current understanding of human biology, development, and diseases. Here, we used a high-throughput yeast two-hybrid (Y2H)-based technology to screen 102 bait proteins from Drosophila melanogaster, most of them orthologous to human cancer-related and/or signaling proteins, against high-complexity fly cDNA libraries. More than 2300 protein-protein interactions (PPI) were identified, of ... [more]
Genome Res. Mar. 01, 2005; 15(3);376-84 [Pubmed: 15710747]
Throughput
- High Throughput
Additional Notes
- Predicted Biological Score:D
Curated By
- BioGRID