BAIT
DREDD
CASP8_DROME, CG7486, DCP-2, DCP-2/DREDD, DCP2, Dedd, Dmel\CG7486, Dredd/DCP-2, EG:115C2.9, Redd, anon-1BCa, dDredd, Dmel_CG7486
Death related ced-3/Nedd2-like protein
GO Process (14)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- apoptotic process [IEP, IGI, NAS, TAS]
- defense response [IMP]
- defense response to Gram-negative bacterium [IMP, TAS]
- immune response [IMP, TAS]
- innate immune response [TAS]
- negative regulation of programmed cell death [IMP]
- peptidoglycan recognition protein signaling pathway [IMP]
- peripheral nervous system neuron development [IMP]
- positive regulation of antibacterial peptide biosynthetic process [NAS, TAS]
- positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria [IMP]
- positive regulation of defense response to virus by host [IMP]
- positive regulation of innate immune response [IMP]
- protein processing [IDA]
- sperm individualization [IMP]
Gene Ontology Molecular Function
Drosophila melanogaster
PREY
MTOR
Bx34, CG8274, Dmel\CG8274, TPR, l(2)k03905, Dmel_CG8274
Megator
GO Process (9)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
- chromatin organization involved in regulation of transcription [IMP]
- chromatin remodeling [IMP]
- mitotic spindle assembly checkpoint [IMP]
- mitotic spindle elongation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of mitotic cell cycle [IMP]
- regulation of mitotic sister chromatid separation [IMP]
- response to endoplasmic reticulum stress [IMP]
- spindle assembly [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interaction mapping: a Drosophila case study.
The Drosophila (fruit fly) model system has been instrumental in our current understanding of human biology, development, and diseases. Here, we used a high-throughput yeast two-hybrid (Y2H)-based technology to screen 102 bait proteins from Drosophila melanogaster, most of them orthologous to human cancer-related and/or signaling proteins, against high-complexity fly cDNA libraries. More than 2300 protein-protein interactions (PPI) were identified, of ... [more]
Genome Res. Mar. 01, 2005; 15(3);376-84 [Pubmed: 15710747]
Throughput
- High Throughput
Additional Notes
- Predicted Biological Score:D
Curated By
- BioGRID