BAIT

CAT2

YCAT, carnitine O-acetyltransferase CAT2, L000000218, YML042W
Carnitine acetyl-CoA transferase; present in both mitochondria and peroxisomes; transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
GO Process (1)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

CPT2

CPT1, CPTASE, IIAE4
carnitine palmitoyltransferase 2
GO Process (3)
GO Function (1)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Carnitine palmitoyltransferase 2: New insights on the substrate specificity and implications for acylcarnitine profiling.

Violante S, Ijlst L, van Lenthe H, de Almeida IT, Wanders RJ, Ventura FV

Over the last years acylcarnitines have emerged as important biomarkers for the diagnosis of mitochondrial fatty acid beta-oxidation (mFAO) and branched-chain amino acid oxidation disorders assuming they reflect the potentially toxic acyl-CoA species, accumulating intramitochondrially upstream of the enzyme block. However, the origin of these intermediates still remains poorly understood. A possibility exists that carnitine palmitoyltransferase 2 (CPT2), member of ... [more]

Unknown Sep. 01, 2010; 1802(9);728-732 [Pubmed: 20538056]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: protein activity (APO:0000022)

Additional Notes

  • Overexpression of human CPT2 rescues the carnitine acetyltransferase activity of a CAT2 mutant

Curated By

  • BioGRID