SRR
Gene Ontology Biological Process
Gene Ontology Molecular Function- ATP binding [IDA, ISS]
- L-serine ammonia-lyase activity [IDA]
- PDZ domain binding [IPI]
- calcium ion binding [ISS]
- glycine binding [ISS]
- magnesium ion binding [IDA]
- protein homodimerization activity [IDA, IPI]
- pyridoxal phosphate binding [IDA, ISS]
- serine racemase activity [IDA]
- threonine racemase activity [ISS]
- ATP binding [IDA, ISS]
- L-serine ammonia-lyase activity [IDA]
- PDZ domain binding [IPI]
- calcium ion binding [ISS]
- glycine binding [ISS]
- magnesium ion binding [IDA]
- protein homodimerization activity [IDA, IPI]
- pyridoxal phosphate binding [IDA, ISS]
- serine racemase activity [IDA]
- threonine racemase activity [ISS]
Gene Ontology Cellular Component
GOLGA3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Modulation of D-serine levels via ubiquitin-dependent proteasomal degradation of serine racemase.
Mammalian serine racemase is a brain-enriched enzyme that converts L- into D-serine in the nervous system. D-Serine is an endogenous co-agonist at the "glycine site" of N-methyl D-aspartate (NMDA) receptors that is required for the receptor/channel opening. Factors regulating the synthesis of D-serine have implications for the NMDA receptor transmission, but little is known on the signals and events affecting ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SRR GOLGA3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID