SEC24
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PDR17
Gene Ontology Biological Process
- Golgi to plasma membrane protein transport [IGI]
- negative regulation of phosphatidylglycerol biosynthetic process [IGI]
- phosphatidylserine metabolic process [IMP]
- phospholipid biosynthetic process [IGI]
- phospholipid transport [IDA, IGI, IMP]
- positive regulation of phosphatidylcholine biosynthetic process [IGI]
- response to drug [IGI]
- sterol biosynthetic process [IGI]
Gene Ontology Molecular Function
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Genetic analysis of yeast Sec24p mutants suggests cargo binding is not co-operative during ER export.
Many eukaryotic secretory proteins are selected for export from the endoplasmic reticulum (ER) through their interaction with the Sec24p subunit of the coat protein II (COPII) coat. Three distinct cargo-binding sites on yeast Sec24p have been described by biochemical, genetic and structural studies. Each site recognizes a limited set of peptide motifs or a folded structural domain, however, the breadth ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SEC24 PDR17 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 154671 |
Curated By
- BioGRID