A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Effect of hydrogen peroxide on antioxidant enzyme activities in Saccharomyces cerevisiae is strain-specific.

Bayliak M, Semchyshyn H, Lushchak V

The effect of hydrogen peroxide on the survival and activity of antioxidant and associated enzymes in Saccharomyces cerevisiae has been studied. A difference found in the response of wild-type yeast strains treated with hydrogen peroxide was probably related to the different protective effects of antioxidant enzymes in these strains. Exposure of wild-type YPH250 cells to 0.25 mM H(2)O(2) for 30 ... [more]

Biochemistry Mosc. Sep. 01, 2006; 71(9);1013-20 [Pubmed: 17009956]

Throughput

Low Throughput

Ontology Terms

phenotype: protein activity (APO:0000022)
phenotype: oxidative stress resistance (APO:0000083)

Additional Notes

double mutants show aberrant enzyme activity in response to hydrogen peroxide exposure

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CTA1 CTT1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Deutscher D (2006)	High	-	BioGRID	348218

Curated By

BioGRID

Interaction Summary

CTA1

Gene Ontology Biological Process

Gene Ontology Molecular Function

catalase activity [IDA, IGI, IMP]

Gene Ontology Cellular Component

CTT1