CLN3
Gene Ontology Biological Process
- action potential [ISS]
- amyloid precursor protein catabolic process [IDA]
- arginine transport [IDA]
- associative learning [ISS]
- autophagic vacuole fusion [ISS]
- cellular amino acid metabolic process [ISS]
- ceramide metabolic process [IDA]
- cytosolic calcium ion homeostasis [ISS]
- galactosylceramide metabolic process [IMP]
- globoside metabolic process [IMP]
- glucosylceramide metabolic process [IMP]
- ionotropic glutamate receptor signaling pathway [ISS]
- lysosomal lumen acidification [IMP]
- lysosomal lumen pH elevation [IDA]
- lysosome organization [ISS]
- macroautophagy [NAS]
- membrane organization [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of catalytic activity [ISS]
- negative regulation of macroautophagy [ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of proteolysis [ISS]
- neuromuscular process controlling balance [ISS]
- neurotransmitter metabolic process [ISS]
- protein catabolic process [NAS]
- protein processing [ISS]
- receptor-mediated endocytosis [IMP]
- sphingomyelin metabolic process [IMP]
- vacuolar transport [IBA]
- vesicle transport along microtubule [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- Golgi membrane [IDA]
- Golgi stack [IDA]
- autophagic vacuole [ISS]
- caveola [IDA]
- cytoplasm [IDA]
- early endosome [IDA]
- endoplasmic reticulum [IDA]
- integral component of endoplasmic reticulum membrane [IDA]
- integral component of membrane [IDA]
- late endosome [IDA, ISS]
- lysosomal membrane [IDA]
- lysosome [IDA]
- membrane raft [IDA]
- mitochondrion [TAS]
- neuron projection [IDA]
- nucleus [IDA]
- plasma membrane [IDA]
- synaptic vesicle [IDA]
- trans-Golgi network [IDA]
RPN2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Network organization of the human autophagy system.
Autophagy, the process by which proteins and organelles are sequestered in autophagosomal vesicles and delivered to the lysosome/vacuole for degradation, provides a primary route for turnover of stable and defective cellular proteins. Defects in this system are linked with numerous human diseases. Although conserved protein kinase, lipid kinase and ubiquitin-like protein conjugation subnetworks controlling autophagosome formation and cargo recruitment have ... [more]
Throughput
- High Throughput
Ontology Terms
- cell line: hek-293 cell (BTO:0000007)
Additional Notes
- Exogenous expression of bait
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CLN3 RPN2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID