BAIT
WIPI2
ATG18B, Atg21, WIPI-2, CGI-50
WD repeat domain, phosphoinositide interacting 2
GO Process (7)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DNM2
CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII, LCCS5
dynamin 2
GO Process (20)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [NAS]
- GTP catabolic process [NAS, TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- endocytosis [NAS]
- membrane organization [TAS]
- negative regulation of membrane tubulation [IDA]
- neuron projection morphogenesis [ISS]
- nitric oxide metabolic process [TAS]
- positive regulation of apoptotic process [NAS]
- positive regulation of transcription, DNA-templated [NAS]
- post-Golgi vesicle-mediated transport [TAS]
- receptor internalization [IMP]
- receptor-mediated endocytosis [ISS]
- regulation of axon extension [ISS]
- regulation of nitric-oxide synthase activity [TAS]
- regulation of transcription, DNA-templated [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
- synaptic vesicle transport [NAS]
- transferrin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Network organization of the human autophagy system.
Autophagy, the process by which proteins and organelles are sequestered in autophagosomal vesicles and delivered to the lysosome/vacuole for degradation, provides a primary route for turnover of stable and defective cellular proteins. Defects in this system are linked with numerous human diseases. Although conserved protein kinase, lipid kinase and ubiquitin-like protein conjugation subnetworks controlling autophagosome formation and cargo recruitment have ... [more]
Nature Jul. 01, 2010; 466(7302);68-76 [Pubmed: 20562859]
Throughput
- High Throughput
Ontology Terms
- cell line: hek-293 cell (BTO:0000007)
Additional Notes
- Exogenous expression of bait
Curated By
- BioGRID