BAIT

ARL1

DLP2, Arf family GTPase ARL1, L000002832, YBR164C
Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; role in membrane organization at trans-Golgi network; G protein of the Ras superfamily, similar to ADP-ribosylation factor
GO Process (4)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

KHA1

YJL094C
Putative K+/H+ antiporter; has a probable role in intracellular cation homeostasis; localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
GO Process (1)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

Genetic interactions among the Arl1 GTPase and intracellular Na(+)sol;H(+) antiporters in pH homeostasis and cation detoxification.

Maresova L, Sychrova H

Abstract The roles of intracellular GTPase Arl1 and organellar cation/H(+) antiporters (Kha1 and Nhx1) in Saccharomyces cerevisiae tolerance to various stress factors were investigated and interesting new phenotypes of strains devoid of these proteins were found. The role of Arl1 GTPase in their tolerance to various cations is not caused by an altered plasma-membrane potential. Besides the known sensitivity of ... [more]

Unknown Jun. 24, 2010; 0(0); [Pubmed: 20659170]

Throughput

  • Low Throughput

Ontology Terms

  • heat sensitivity (APO:0000147)
  • chemical compound accumulation (APO:0000095)
  • vegetative growth (APO:0000106)

Additional Notes

  • ENA1/NHA1/ARL1/KHA1/NHX1 quintuple mutants show increased sensitivity to and build up of lithium
  • double mutant shows increased sensitivity to copper, sodium chloride and potassium chloride
  • genetic complex

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
ARL1 KHA1
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-BioGRID
657197

Curated By

  • BioGRID