A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Combinatorial, site-specific requirement for heterochromatic silencing factors in the elimination of nucleosome-free regions.

Garcia JF, Dumesic PA, Hartley PD, El-Samad H, Madhani HD

High-resolution nucleosome occupancy maps of heterochromatic regions of wild-type and silencing-defective mutants of the fission yeast Schizosaccharomyces pombe revealed that heterochromatin induces the elimination of nucleosome-free regions (NFRs). NFRs associated with transcription initiation sites as well as those not associated with promoters are affected. We dissected the roles of the histone H3K9 methyltransferase Clr4 and the HP1 proteins Swi6 and ... [more]

Genes Dev. Aug. 15, 2010; 24(16);1758-71 [Pubmed: 20675407]

Throughput

Low Throughput

Ontology Terms

phenotype: protein/peptide distribution (APO:0000209)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
RSC1 CLR3	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Roguev A (2008)	High	-4.1671	BioGRID	525641

Curated By

BioGRID

Interaction Summary

CLR3

Gene Ontology Biological Process

Gene Ontology Molecular Function

histone deacetylase activity [IDA, IMP]histone deacetylase activity (H3-K14 specific) [IMP]

Gene Ontology Cellular Component

RSC1