Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Crossover invariance determined by partner choice for meiotic DNA break repair.

Hyppa RW, Smith GR

Crossovers between meiotic homologs are crucial for their proper segregation, and crossover number and position are carefully controlled. Crossover homeostasis in budding yeast maintains crossovers at the expense of noncrossovers when double-strand DNA break (DSB) frequency is reduced. The mechanism of maintaining constant crossover levels in other species has been unknown. Here we investigate in fission yeast a different aspect ... [more]

Cell Jul. 23, 2010; 142(2);243-55 [Pubmed: 20655467]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: meiotic recombination (APO:0000040)

Additional Notes

  • double mutants show increased loss of double holiday junctures compared to single mutants

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
SWI5 MUS81
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
247969

Curated By

  • BioGRID