CDC15
Gene Ontology Biological Process
- actin cytoskeleton organization [IMP]
- cortical actin cytoskeleton organization [IMP]
- establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site [IMP]
- mitotic actomyosin contractile ring assembly [IMP]
- mitotic actomyosin contractile ring localization [IMP]
- protein localization to cell division site involved in cytokinesis, actomyosin contractile ring assembly [IMP]
- regulation of actin nucleation [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RNG2
Gene Ontology Biological Process
- actin filament bundle assembly [IDA]
- actomyosin contractile ring actin filament bundle assembly [IDA]
- actomyosin contractile ring assembly actin filament bundle convergence [IDA]
- mitotic actomyosin contractile ring assembly [IMP]
- mitotic actomyosin contractile ring assembly actin filament organization [IMP]
- mitotic actomyosin contractile ring localization [IMP]
- mitotic cytokinesis [IMP]
- protein localization to medial cortex [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.
Cytokinesis in Schizosaccharomyces pombe requires the function of Cdc15, the founding member of the pombe cdc15 homology (PCH) family of proteins. As an early, abundant contractile ring component with multiple binding partners, Cdc15 plays a key role in organizing the ring. We demonstrate that Cdc15 phosphorylation at many sites generates a closed conformation, inhibits Cdc15 assembly at the division site ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RNG2 CDC15 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| CDC15 RNG2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CDC15 RNG2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | PomBase | - | |
| CDC15 RNG2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 559630 |
Curated By
- BioGRID