BAIT

SNCA

NACP, PARK1, PARK4, PD1
synuclein, alpha (non A4 component of amyloid precursor)
GO Process (45)
GO Function (20)
GO Component (16)

Gene Ontology Biological Process

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions.

McFarland MA, Ellis CE, Markey SP, Nussbaum RL

Mutations and copy number variation in the SNCA gene encoding the neuronal protein alpha-synuclein have been linked to familial Parkinson disease (Thomas, B., and Beal, M. F. (2007) Parkinson's disease. Hum. Mol. Genet. 16, R183-R194). The carboxyl terminus of alpha-synuclein can be phosphorylated at tyrosine 125 and serine 129, although only a small fraction of the protein is phosphorylated under ... [more]

Mol. Cell Proteomics Nov. 01, 2008; 7(11);2123-37 [Pubmed: 18614564]

Throughput

  • Low Throughput

Additional Notes

  • Bait has preferential affinity for the Ser-129 phosphorylated alpha-synuclein

Curated By

  • BioGRID