TOR1
Gene Ontology Biological Process
- TOR signaling [TAS]
- cell aging [TAS]
- cellular response to nitrogen starvation [IMP]
- cellular response to osmotic stress [IMP]
- phosphatidylinositol-mediated signaling [NAS]
- positive regulation of conjugation with cellular fusion [IMP]
- regulation of conjugation with cellular fusion [IMP]
- response to temperature stimulus [IMP]
Gene Ontology Molecular Function
CDC25
Gene Ontology Biological Process
- mitotic DNA replication checkpoint [IMP]
- peptidyl-tyrosine dephosphorylation involved in activation of protein kinase activity [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle [IMP]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of cell size [NAS]
- signal transduction involved in intra-S DNA damage checkpoint [IMP]
Gene Ontology Molecular Function
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions.
The Target Of Rapamycin (TOR) kinase belongs to the highly conserved eukaryotic family of phosphatidylinositol-3-kinase-related kinases (PIKKs). TOR proteins are found at the core of two distinct evolutionarily conserved complexes, TORC1 and TORC2. Disruption of TORC1 or TORC2 results in characteristically dissimilar phenotypes. TORC1 is a major cell growth regulator, while the cellular roles of TORC2 are not well understood. ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- Triple mutant: tor1/wee1/cdc25 is lethal
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC25 TOR1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 349596 |
Curated By
- BioGRID