BAIT
DNT1
SPBC25D12.02c
nucleolar protein Dnt1
GO Process (5)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
- chromatin silencing at rDNA [IMP]
- negative regulation of protein localization to mitotic spindle pole body [IMP]
- negative regulation of septation initiation signaling [IGI]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [IMP]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
PREY
NUC1
rpa1, rpa190, SPBC4C3.05c
DNA-directed RNA polymerase I complex large subunit Nuc1
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The nucleolar Net1/Cfi1-related protein Dnt1 antagonizes the septation initiation network in fission yeast.
The septation initiation network (SIN) and mitotic exit network (MEN) signaling pathways regulate cytokinesis and mitotic exit in the yeasts Schizosaccharomyces pombe, and Saccharomyces cerevisiae, respectively. One function of these pathways is to keep the Cdc14-family phosphatase, called Clp1 in S. pombe, from being sequestered and inhibited in the nucleolus. In S. pombe, the SIN and Clp1 act as part ... [more]
Mol. Biol. Cell Aug. 01, 2007; 18(8);2924-34 [Pubmed: 17538026]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID