BAIT
KRE1
L000000912, YNL322C
Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
GO Process (1)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
CAP2
F-actin-capping protein subunit beta, L000000215, YIL034C
Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress
GO Process (2)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function- actin filament binding [IGI, IMP, IPI, ISS]
- actin filament binding [IGI, IMP, IPI, ISS]
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Global mapping of the yeast genetic interaction network.
A genetic interaction network containing approximately 1000 genes and approximately 4000 interactions was mapped by crossing mutations in 132 different query genes into a set of approximately 4700 viable gene yeast deletion mutants and scoring the double mutant progeny for fitness defects. Network connectivity was predictive of function because interactions often occurred among functionally related genes, and similar patterns of ... [more]
Science Feb. 06, 2004; 303(5659);808-13 [Pubmed: 14764870]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- genetic complex
- triple mutants show synthetic lethality compared to a BNI1/KRE1 double mutant
Curated By
- BioGRID