PRMT5
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- cell proliferation [TAS]
- circadian regulation of gene expression [ISS]
- endothelial cell activation [IMP]
- gene expression [TAS]
- histone H4-R3 methylation [ISS, NAS]
- ncRNA metabolic process [TAS]
- peptidyl-arginine N-methylation [IDA]
- peptidyl-arginine methylation [IMP]
- peptidyl-arginine methylation, to symmetrical-dimethyl arginine [IMP]
- regulation of mitosis [TAS]
- regulation of transcription, DNA-templated [IBA]
- spliceosomal snRNP assembly [IMP, TAS]
Gene Ontology Molecular Function
MYOG
Gene Ontology Biological Process
- cellular response to estradiol stimulus [ISS]
- mRNA transcription from RNA polymerase II promoter [TAS]
- muscle cell differentiation [TAS]
- muscle cell fate commitment [ISS]
- negative regulation of cell proliferation [ISS]
- positive regulation of cell cycle arrest [ISS]
- positive regulation of muscle atrophy [ISS]
- positive regulation of muscle cell differentiation [TAS]
- positive regulation of myoblast differentiation [ISS]
- positive regulation of myotube differentiation [ISS]
- positive regulation of skeletal muscle fiber development [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- regulation of myoblast fusion [ISS]
- regulation of satellite cell proliferation [ISS]
- response to denervation involved in regulation of muscle adaptation [ISS]
- response to electrical stimulus involved in regulation of muscle adaptation [ISS]
- response to muscle activity involved in regulation of muscle adaptation [ISS]
- skeletal muscle tissue development [TAS]
- striated muscle atrophy [ISS]
Gene Ontology Molecular Function- E-box binding [ISS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA, ISS]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, TAS]
- chromatin DNA binding [ISS]
- core promoter binding [ISS]
- protein heterodimerization activity [ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISS]
- E-box binding [ISS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA, ISS]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, TAS]
- chromatin DNA binding [ISS]
- core promoter binding [ISS]
- protein heterodimerization activity [ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISS]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation.
Temporal regulation of gene expression is a hallmark of cellular differentiation pathways, yet the mechanisms controlling the timing of expression for different classes of differentiation-specific genes are not well understood. We previously demonstrated that the class II arginine methyltransferase Prmt5 was required for skeletal muscle differentiation at the early stages of myogenesis (C. S. Dacwag, Y. Ohkawa, S. Pal, S. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID