WIF1
Gene Ontology Biological Process
Gene Ontology Molecular Function
WNT1
Gene Ontology Biological Process
- Spemann organizer formation [ISS]
- Wnt signaling pathway [IDA]
- bone development [IMP]
- canonical Wnt signaling pathway [IMP]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [IMP]
- cell fate commitment [IBA]
- cell-cell signaling [ISS]
- central nervous system morphogenesis [ISS]
- cerebellum formation [ISS]
- embryonic axis specification [ISS]
- midbrain development [ISS]
- negative regulation of BMP signaling pathway [IMP]
- negative regulation of cell aging [IDA]
- negative regulation of cell-cell adhesion [IMP]
- negative regulation of cell-substrate adhesion [IDA]
- negative regulation of fat cell differentiation [ISS]
- neuron differentiation [IBA]
- positive regulation of Notch signaling pathway [IDA]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of dermatome development [IDA]
- positive regulation of fibroblast proliferation [IMP]
- positive regulation of insulin-like growth factor receptor signaling pathway [IDA]
- positive regulation of lamellipodium assembly [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISS]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISS]
- response to wounding [IEP]
- signal transduction in response to DNA damage [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells.
Epigenetic silencing of secreted wingless-type (Wnt) antagonists through hypermethylation is associated with tobacco smoking and with invasive bladder cancer. The secreted Wnt inhibitory factor-1 (WIF1) has shown consistent growth-inhibitory effect on various cancer cell lines. Therefore, we assessed the mechanisms of action of WIF1 by either restoring WIF1 expression in invasive bladder cancer cell lines (T24 and TSU-PR1) or using ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID