BAIT

GIGYF2

GYF2, PARK11, PERQ2, PERQ3, TNRC15

GRB10 interacting GYF protein 2

GO Process (1)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

negative regulation of translation [IMP]

Gene Ontology Molecular Function

poly(A) RNA binding [IDA]

Gene Ontology Cellular Component

cytoplasm [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB HPRD

Homo sapiens

PREY

AGO2

EIF2C2, Q10

argonaute RISC catalytic component 2

GO Process (18)

GO Function (7)

GO Component (9)

Gene Ontology Biological Process

Fc-epsilon receptor signaling pathway [TAS]

Notch signaling pathway [TAS]

RNA phosphodiester bond hydrolysis, endonucleolytic [EXP, IDA]

epidermal growth factor receptor signaling pathway [TAS]

fibroblast growth factor receptor signaling pathway [TAS]

gene expression [TAS]

gene silencing by RNA [ISS]

innate immune response [TAS]

mRNA cleavage involved in gene silencing by miRNA [IDA, IMP]

negative regulation of translation involved in gene silencing by miRNA [IDA, IMP]

negative regulation of translational initiation [IDA]

neurotrophin TRK receptor signaling pathway [TAS]

phosphatidylinositol-mediated signaling [TAS]

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [ISS]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [ISS]

pre-miRNA processing [IDA]

translation [NAS]

translational initiation [NAS]

Gene Ontology Molecular Function

RNA 7-methylguanosine cap binding [IDA]
endoribonuclease activity [EXP]
endoribonuclease activity, cleaving siRNA-paired mRNA [IDA]
poly(A) RNA binding [IDA]
protein binding [IPI]
siRNA binding [IDA]
translation initiation factor activity [NAS]

Gene Ontology Cellular Component

RISC complex [IDA]

cytoplasm [IDA]

cytoplasmic mRNA processing body [IDA]

mRNA cap binding complex [IDA]

micro-ribonucleoprotein complex [IDA]

ribonucleoprotein complex [IDA]

CRISPR Database OMIM VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes.

Ash MR, Faelber K, Kosslick D, Albert GI, Roske Y, Kofler M, Schuemann M, Krause E, Freund C

The yeast suppressor of myosin 2 protein (Smy2) interacts with mRNA-processing proteins through recognition of proline-rich sequences (PRS). Here, we describe the crystal structure of the GYF domain of Smy2 in association with a PRS from the yeast branch point binding protein (BBP/ScSF1). Complex formation requires that the beta-hairpin of the central PPGL motif of the ligand is accommodated by ... [more]

Structure Aug. 11, 2010; 18(8);944-54 [Pubmed: 20696395]

Throughput

Low Throughput

Curated By

BioGRID