BAIT

GIGYF2

GYF2, PARK11, PERQ2, PERQ3, TNRC15
GRB10 interacting GYF protein 2
GO Process (1)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

CAPRIN1

GPIAP1, GPIP137, GRIP137, M11S1, RNG105, p137GPI
cell cycle associated protein 1
Autism spectrum disorder (ASD) Project
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes.

Ash MR, Faelber K, Kosslick D, Albert GI, Roske Y, Kofler M, Schuemann M, Krause E, Freund C

The yeast suppressor of myosin 2 protein (Smy2) interacts with mRNA-processing proteins through recognition of proline-rich sequences (PRS). Here, we describe the crystal structure of the GYF domain of Smy2 in association with a PRS from the yeast branch point binding protein (BBP/ScSF1). Complex formation requires that the beta-hairpin of the central PPGL motif of the ligand is accommodated by ... [more]

Structure Aug. 11, 2010; 18(8);944-54 [Pubmed: 20696395]

Throughput

  • Low Throughput

Curated By

  • BioGRID