MMS22
Gene Ontology Biological Process
Gene Ontology Cellular Component
MRE11
Gene Ontology Biological Process
- DNA double-strand break processing involved in repair via synthesis-dependent strand annealing [IMP]
- DNA repair [IMP]
- ascospore formation [IMP]
- base-excision repair [IMP]
- double-strand break repair via break-induced replication [IGI, IMP]
- double-strand break repair via nonhomologous end joining [IMP]
- meiotic DNA double-strand break formation [TAS]
- meiotic DNA double-strand break processing [TAS]
- mitochondrial double-strand break repair via homologous recombination [IMP]
- reciprocal meiotic recombination [IMP]
- regulation of transcription during meiosis [IMP]
Gene Ontology Molecular Function- 3'-5' exonuclease activity [IDA]
- G-quadruplex DNA binding [IDA]
- adenylate kinase activity [IDA]
- double-stranded telomeric DNA binding [IDA]
- endodeoxyribonuclease activity [IDA]
- endonuclease activity [IDA]
- protein complex scaffold [IGI, IMP]
- single-stranded telomeric DNA binding [IDA]
- telomeric DNA binding [IDA]
- 3'-5' exonuclease activity [IDA]
- G-quadruplex DNA binding [IDA]
- adenylate kinase activity [IDA]
- double-stranded telomeric DNA binding [IDA]
- endodeoxyribonuclease activity [IDA]
- endonuclease activity [IDA]
- protein complex scaffold [IGI, IMP]
- single-stranded telomeric DNA binding [IDA]
- telomeric DNA binding [IDA]
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A DNA integrity network in the yeast Saccharomyces cerevisiae.
A network governing DNA integrity was identified in yeast by a global genetic analysis of synthetic fitness or lethality defect (SFL) interactions. Within this network, 16 functional modules or minipathways were defined based on patterns of global SFL interactions. Modules or genes involved in DNA replication, DNA-replication checkpoint (DRC) signaling, and oxidative stress response were identified as the major guardians ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- synthetic growth defect confirmed by RSA and synthetic lethality confirmed by tetrad analysis
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MRE11 MMS22 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | High | - | BioGRID | 457658 |
Curated By
- BioGRID