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BAIT

CTF8

L000003309, YHR191C

Subunit of a complex with Ctf18p; shares some subunits with Replication Factor C; required for sister chromatid cohesion

GO Process (2)

GO Function (0)

GO Component (1)

Gene Ontology Biological Process

maintenance of DNA trinucleotide repeats [IMP]

mitotic sister chromatid cohesion [IGI, IMP]

Gene Ontology Cellular Component

Ctf18 RFC-like complex [IPI]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

PREY

POP2

CAF1, CCR4-NOT core DEDD family RNase subunit POP2, L000001465, YNR052C

RNase of the DEDD superfamily; subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation

GO Process (4)

GO Function (1)

GO Component (4)

Gene Ontology Biological Process

nuclear-transcribed mRNA poly(A) tail shortening [IDA, IMP]

positive regulation of transcription elongation from RNA polymerase II promoter [IDA, IPI]

regulation of transcription from RNA polymerase II promoter [IPI]

transcription elongation from RNA polymerase II promoter [IMP]

Gene Ontology Molecular Function

3'-5'-exoribonuclease activity [IDA, IGI, IMP]

Gene Ontology Cellular Component

CCR4-NOT core complex [IPI]

cytoplasm [IDA]

cytoplasmic mRNA processing body [IDA]

mating projection tip [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

A DNA integrity network in the yeast Saccharomyces cerevisiae.

Pan X, Ye P, Yuan DS, Wang X, Bader JS, Boeke JD

A network governing DNA integrity was identified in yeast by a global genetic analysis of synthetic fitness or lethality defect (SFL) interactions. Within this network, 16 functional modules or minipathways were defined based on patterns of global SFL interactions. Modules or genes involved in DNA replication, DNA-replication checkpoint (DRC) signaling, and oxidative stress response were identified as the major guardians ... [more]

Cell Mar. 10, 2006; 124(5);1069-81 [Pubmed: 16487579]

Throughput

High Throughput

Ontology Terms

phenotype: vegetative growth (APO:0000106)

Additional Notes

confirmed by RSA

Curated By

BioGRID