RPN4
Gene Ontology Biological Process
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter in response to stress [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to stress [IEP, IMP]
- regulation of DNA repair [IMP]
Gene Ontology Molecular Function
UME6
Gene Ontology Biological Process
- chromatin remodeling [IMP]
- lipid particle organization [IMP]
- negative regulation of inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter during meiosis [IMP]
- negative regulation of transcription from RNA polymerase II promoter during mitosis [IMP]
- nitrogen catabolite repression of transcription from RNA polymerase II promoter [IMP]
- positive regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of phosphatidylcholine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter during meiosis [IMP]
- pseudohyphal growth [IMP]
- spore germination [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- repressing transcription factor binding [IDA, IPI]
- sequence-specific DNA binding [IDA]
- transcription factor binding transcription factor activity [IGI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- repressing transcription factor binding [IDA, IPI]
- sequence-specific DNA binding [IDA]
- transcription factor binding transcription factor activity [IGI]
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
A DNA integrity network in the yeast Saccharomyces cerevisiae.
A network governing DNA integrity was identified in yeast by a global genetic analysis of synthetic fitness or lethality defect (SFL) interactions. Within this network, 16 functional modules or minipathways were defined based on patterns of global SFL interactions. Modules or genes involved in DNA replication, DNA-replication checkpoint (DRC) signaling, and oxidative stress response were identified as the major guardians ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- confirmed by RSA
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UME6 RPN4 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -7.9835 | BioGRID | 541053 | |
| UME6 RPN4 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.4986 | BioGRID | 220776 | |
| RPN4 UME6 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1653 | BioGRID | 364731 | |
| UME6 RPN4 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2724 | BioGRID | 2097720 | |
| UME6 RPN4 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | High | - | BioGRID | 3675459 |
Curated By
- BioGRID