BAIT
POP2
CAF1, CCR4-NOT core DEDD family RNase subunit POP2, L000001465, YNR052C
RNase of the DEDD superfamily; subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation
GO Process (4)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
PIM1
ATP-dependent Lon protease PIM1, LON1, L000000949, L000001440, YBL022C
ATP-dependent Lon protease; involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
GO Process (7)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- cellular response to oxidative stress [IBA]
- chaperone-mediated protein complex assembly [IGI]
- misfolded or incompletely synthesized protein catabolic process [IGI, IMP]
- mitochondrion organization [IBA]
- oxidation-dependent protein catabolic process [IBA]
- protein homooligomerization [IBA]
- response to hypoxia [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A DNA integrity network in the yeast Saccharomyces cerevisiae.
A network governing DNA integrity was identified in yeast by a global genetic analysis of synthetic fitness or lethality defect (SFL) interactions. Within this network, 16 functional modules or minipathways were defined based on patterns of global SFL interactions. Modules or genes involved in DNA replication, DNA-replication checkpoint (DRC) signaling, and oxidative stress response were identified as the major guardians ... [more]
Cell Mar. 10, 2006; 124(5);1069-81 [Pubmed: 16487579]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- confirmed by RSA
Curated By
- BioGRID