BAIT
PAP2
TRF4, non-canonical poly(A) polymerase PAP2, L000002953, YOL115W
Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of TRAMP; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; required for mRNA surveillance and maintenance of genome integrity, serving as a link between RNA and DNA metabolism; overlapping but non-redundant functions with Trf5p; relocalizes to cytosol in response to hypoxia
GO Process (18)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- U4 snRNA 3'-end processing [IGI, IMP]
- base-excision repair [IGI, IMP]
- histone mRNA catabolic process [IGI]
- meiotic DNA double-strand break formation [IMP]
- ncRNA polyadenylation [IDA, IGI, IMP]
- negative regulation of DNA recombination [IMP]
- nuclear mRNA surveillance of mRNA 3'-end processing [IGI]
- nuclear polyadenylation-dependent CUT catabolic process [IGI, IMP]
- nuclear polyadenylation-dependent antisense transcript catabolic process [IMP]
- nuclear polyadenylation-dependent mRNA catabolic process [IGI]
- nuclear polyadenylation-dependent rRNA catabolic process [IGI, IMP]
- nuclear polyadenylation-dependent snRNA catabolic process [IMP]
- nuclear polyadenylation-dependent snoRNA catabolic process [IGI, IMP]
- nuclear polyadenylation-dependent tRNA catabolic process [IDA, IGI, IMP]
- polyadenylation-dependent mRNA catabolic process [IMP]
- polyadenylation-dependent snoRNA 3'-end processing [IGI]
- snoRNA polyadenylation [IGI]
- tRNA modification [IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
SLA2
END4, MOP2, L000001913, L000002421, YNL243W
Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo
GO Process (5)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A DNA integrity network in the yeast Saccharomyces cerevisiae.
A network governing DNA integrity was identified in yeast by a global genetic analysis of synthetic fitness or lethality defect (SFL) interactions. Within this network, 16 functional modules or minipathways were defined based on patterns of global SFL interactions. Modules or genes involved in DNA replication, DNA-replication checkpoint (DRC) signaling, and oxidative stress response were identified as the major guardians ... [more]
Cell Mar. 10, 2006; 124(5);1069-81 [Pubmed: 16487579]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- confirmed by RSA
Curated By
- BioGRID