CDKN2A
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA]
- Ras protein signal transduction [IEP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- apoptotic mitochondrial changes [IMP]
- cell cycle arrest [IDA, IMP]
- cellular senescence [IMP]
- mitotic cell cycle [TAS]
- negative regulation of B cell proliferation [ISS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of cell-matrix adhesion [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- negative regulation of immature T cell proliferation in thymus [ISS]
- negative regulation of phosphorylation [IDA]
- negative regulation of protein kinase activity [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- negative regulation of ubiquitin-protein transferase activity [ISS]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of cellular senescence [IMP]
- positive regulation of macrophage apoptotic process [ISS]
- positive regulation of protein sumoylation [IMP]
- positive regulation of smooth muscle cell apoptotic process [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein K63-linked ubiquitination [IDA]
- protein destabilization [IDA]
- protein polyubiquitination [IDA]
- protein stabilization [IDA]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of apoptotic DNA fragmentation [IMP]
- regulation of protein export from nucleus [IMP]
- regulation of protein stability [ISS]
- replicative senescence [IMP]
- senescence-associated heterochromatin focus assembly [IMP]
- somatic stem cell division [ISS]
Gene Ontology Molecular Function- MDM2/MDM4 family protein binding [IPI]
- NF-kappaB binding [IDA]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IDA]
- p53 binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- transcription factor binding [IPI]
- ubiquitin-protein transferase inhibitor activity [ISS]
- MDM2/MDM4 family protein binding [IPI]
- NF-kappaB binding [IDA]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IDA]
- p53 binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- transcription factor binding [IPI]
- ubiquitin-protein transferase inhibitor activity [ISS]
Gene Ontology Cellular Component
SMARCA4
Gene Ontology Biological Process
- ATP catabolic process [IGI]
- ATP-dependent chromatin remodeling [IDA]
- chromatin remodeling [IC, IDA]
- negative regulation of G1/S transition of mitotic cell cycle [TAS]
- negative regulation of androgen receptor signaling pathway [IMP]
- negative regulation of cell growth [IMP]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transcription from RNA polymerase II promoter during mitosis [TAS]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- neural retina development [IEP]
- nucleosome disassembly [IDA]
- positive regulation by host of viral transcription [IMP]
- positive regulation of Wnt signaling pathway [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of transcription from RNA polymerase II promoter [NAS]
Gene Ontology Molecular Function- DNA polymerase binding [IPI]
- DNA-dependent ATPase activity [IGI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II transcription coactivator activity [IDA]
- Tat protein binding [IPI]
- androgen receptor binding [IPI]
- lysine-acetylated histone binding [IDA]
- nucleosomal DNA binding [IDA]
- p53 binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IMP, NAS]
- transcription corepressor activity [IDA]
- DNA polymerase binding [IPI]
- DNA-dependent ATPase activity [IGI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II transcription coactivator activity [IDA]
- Tat protein binding [IPI]
- androgen receptor binding [IPI]
- lysine-acetylated histone binding [IDA]
- nucleosomal DNA binding [IDA]
- p53 binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IMP, NAS]
- transcription corepressor activity [IDA]
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a.
BACKGROUND: CDKN2A/p16INK4a is frequently altered in human cancers and it is the most important melanoma susceptibility gene identified to date. p16INK4a inhibits pRb phosphorylation and induces cell cycle arrest, which is considered its main tumour suppressor function. Nevertheless, additional activities may contribute to the tumour suppressor role of p16INK4a and could help explain its specific association with melanoma predisposition. To ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDKN2A SMARCA4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID