BAIT
PTC
BcDNA:RH36596, CG2411, Conf, Dmel\CG2411, Ptc_Dm, Ptch, com4, dPtc, l(2)k02507, pat, rubr, tuf, Dmel_CG2411
patched
GO Process (25)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- Bolwig's organ morphogenesis [IMP]
- anterior/posterior lineage restriction, imaginal disc [TAS]
- anterior/posterior pattern specification [NAS]
- axon guidance [IMP]
- blastoderm segmentation [NAS]
- dephosphorylation [TAS]
- determination of genital disc primordium [IMP]
- embryonic pattern specification [TAS]
- eye-antennal disc morphogenesis [IMP]
- germ-line stem cell division [TAS]
- gonad development [IMP]
- imaginal disc-derived wing morphogenesis [IMP]
- lipid homeostasis [IMP]
- negative regulation of smoothened signaling pathway [IGI, TAS]
- oogenesis [IMP]
- ovarian follicle cell development [TAS]
- peripheral nervous system development [TAS]
- proteolysis [TAS]
- regulation of apoptotic process [IGI]
- regulation of epithelial cell migration, open tracheal system [IMP]
- regulation of mitotic cell cycle [IMP]
- regulation of protein import into nucleus [IMP]
- smoothened signaling pathway [IGI, IMP, NAS, TAS]
- somatic stem cell division [TAS]
- wing disc anterior/posterior pattern formation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
PREY
FHOS
CG32025, CG32030, CG42610, CG5775, CG5797, Dmel\CG42610, Dmel_CG32025, Dmel_CG32030, dFHOS, desert, jaz, knit, l(3)01629, Dmel_CG42610
Formin homology 2 domain containing ortholog
GO Process (10)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- developmental programmed cell death [IMP]
- imaginal disc-derived wing morphogenesis [IMP]
- muscle cell cellular homeostasis [IGI, IMP]
- muscle system process [IEP, IGI]
- positive regulation of cell migration [IMP]
- positive regulation of stress fiber assembly [IGI, IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IMP]
- salivary gland histolysis [IMP]
- trachea morphogenesis [IMP]
- wound healing, spreading of cells [IMP]
Gene Ontology Molecular Function
Drosophila melanogaster
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interaction mapping: a Drosophila case study.
The Drosophila (fruit fly) model system has been instrumental in our current understanding of human biology, development, and diseases. Here, we used a high-throughput yeast two-hybrid (Y2H)-based technology to screen 102 bait proteins from Drosophila melanogaster, most of them orthologous to human cancer-related and/or signaling proteins, against high-complexity fly cDNA libraries. More than 2300 protein-protein interactions (PPI) were identified, of ... [more]
Genome Res. Mar. 01, 2005; 15(3);376-84 [Pubmed: 15710747]
Throughput
- High Throughput
Curated By
- BioGRID