BAIT

RPO41

L000001747, YFL036W
Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
GO Process (2)
GO Function (1)
GO Component (5)
Saccharomyces cerevisiae (S288c)
PREY

TAR1

YLR154W-A, S000007646, YLR154W-C
Protein potentially involved in regulation of respiratory metabolism; located in the mitochondria; interacts genetically with RPO41 and physically with Coq5p; encoded within the 25S rRNA gene on the opposite strand
GO Process (1)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Expression of the rDNA-encoded mitochondrial protein Tar1p is stringently controlled and responds differentially to mitochondrial respiratory demand and dysfunction.

Bonawitz ND, Chatenay-Lapointe M, Wearn CM, Shadel GS

The novel yeast protein Tar1p is encoded on the anti-sense strand of the multi-copy nuclear 25S rRNA gene, localizes to mitochondria, and partially suppresses the mitochondrial RNA polymerase mutant, rpo41-R129D. However, the function of Tar1p in mitochondria and how its expression is regulated are currently unknown. Here we report that Tar1p is subject to glucose repression and is up-regulated during ... [more]

Curr. Genet. Aug. 01, 2008; 54(2);83-94 [Pubmed: 18622616]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: oxidative phosphorylation (APO:0000145)
  • phenotype: lifespan (APO:0000030)

Curated By

  • BioGRID