BAIT

BOP2

L000004722, YLR267W

Protein of unknown function

GO Process (0)

GO Function (0)

GO Component (0)

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

PREY

TRS85

GSG1, MUM1, L000002779, S000029315, L000002585, YDR108W

Component of transport protein particle (TRAPP) complex III; TRAPPIII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating endosome-Golgi traffic and required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role

GO Process (9)

GO Function (0)

GO Component (4)

Gene Ontology Biological Process

CVT pathway [IMP]

ER to Golgi vesicle-mediated transport [IGI, IMP]

autophagic vacuole assembly [IMP]

macroautophagy [IMP]

meiotic nuclear division [IMP]

peroxisome degradation [IMP]

piecemeal microautophagy of nucleus [IMP]

protein localization to pre-autophagosomal structure [IMP]

vesicle organization [IMP]

Gene Ontology Cellular Component

Golgi apparatus [IDA]

TRAPPIII protein complex [IDA]

cytoplasmic vesicle [IDA]

pre-autophagosomal structure [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.

Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman JS, Schuldiner M

Protein folding in the endoplasmic reticulum is a complex process whose malfunction is implicated in disease and aging. By using the cell's endogenous sensor (the unfolded protein response), we identified several hundred yeast genes with roles in endoplasmic reticulum folding and systematically characterized their functional interdependencies by measuring unfolded protein response levels in double mutants. This strategy revealed multiple conserved ... [more]

Science Mar. 27, 2009; 323(5922);1693-7 [Pubmed: 19325107]

Throughput

High Throughput

Ontology Terms

phenotype: protein/peptide accumulation (APO:0000149)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
TRS85 BOP2	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2016)	High	-0.128	BioGRID	2094994
TRS85 BOP2	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Jonikas MC (2009)	High	-	BioGRID	461314

Curated By

BioGRID

Interaction Summary