PREY

DNM1L

DLP1, DRP1, DVLP, DYMPLE, EMPF, HDYNIV
dynamin 1-like
Homo sapiens

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

PEX11 family members are membrane elongation factors that coordinate peroxisome proliferation and maintenance.

Koch J, Pranjic K, Huber A, Ellinger A, Hartig A, Kragler F, Brocard C

Dynamic changes of membrane structure are intrinsic to organelle morphogenesis and homeostasis. Ectopic expression of proteins of the PEX11 family from yeast, plant or human lead to the formation of juxtaposed elongated peroxisomes (JEPs),which is evocative of an evolutionary conserved function of these proteins in membrane tubulation. Microscopic examinations reveal that JEPs are composed of independent elongated peroxisomes with heterogeneous ... [more]

Unknown Sep. 07, 2010; 0(0); [Pubmed: 20826455]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: peroxisomal morphology (APO:0000058)

Additional Notes

  • DRP1 increases the formation of juxtaposed elongated peroxisomes formed by PEX11

Curated By

  • BioGRID