BAIT
AFF1
AF4, MLLT2, PBM1
AF4/FMR2 family, member 1
GO Process (0)
GO Function (2)
GO Component (1)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NT5E
CALJA, CD73, E5NT, NT, NT5, NTE, eN, eNT, RP11-321N4.1
5'-nucleotidase, ecto (CD73)
GO Process (8)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
- DNA metabolic process [TAS]
- dephosphorylation [EXP, TAS]
- nucleobase-containing small molecule metabolic process [TAS]
- purine nucleobase metabolic process [TAS]
- purine nucleotide catabolic process [TAS]
- pyrimidine nucleobase metabolic process [TAS]
- pyrimidine nucleoside catabolic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Misguided transcriptional elongation causes mixed lineage leukemia.
Fusion proteins composed of the histone methyltransferase mixed-lineage leukemia (MLL) and a variety of unrelated fusion partners are highly leukemogenic. Despite their prevalence, particularly in pediatric acute leukemia, many molecular details of their transforming mechanism are unknown. Here, we provide mechanistic insight into the function of MLL fusions, demonstrating that they capture a transcriptional elongation complex that has been previously ... [more]
PLoS Biol. Nov. 01, 2009; 7(11);e1000249 [Pubmed: 19956800]
Throughput
- Low Throughput
Curated By
- BioGRID