BAIT
MAPK6
ERK3, HsT17250, PRKM6, p97MAPK
mitogen-activated protein kinase 6
GO Process (3)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
ANK3
ANKYRIN-G, MRT37, RP11-369L1.1
ankyrin 3, node of Ranvier (ankyrin G)
GO Process (17)
GO Function (7)
GO Component (14)
Gene Ontology Biological Process
- Golgi to plasma membrane protein transport [IMP]
- axonogenesis [ISS]
- cytoskeletal anchoring at plasma membrane [TAS]
- establishment of protein localization [IMP]
- maintenance of protein location in plasma membrane [IGI]
- membrane assembly [IMP]
- mitotic cytokinesis [IMP]
- neuronal action potential [ISS]
- plasma membrane organization [IMP]
- positive regulation of gene expression [ISS]
- positive regulation of membrane depolarization during cardiac muscle cell action potential [ISS]
- positive regulation of membrane potential [ISS]
- positive regulation of sodium ion transmembrane transporter activity [ISS]
- positive regulation of sodium ion transport [ISS]
- protein localization to plasma membrane [IGI, IMP]
- protein targeting to plasma membrane [IMP]
- regulation of potassium ion transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISS]
- axon initial segment [ISS]
- basal plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- cell surface [ISS]
- costamere [TAS]
- endoplasmic reticulum [TAS]
- intercalated disc [ISS]
- lateral plasma membrane [IDA]
- node of Ranvier [ISS]
- plasma membrane [ISS]
- sarcolemma [IDA]
- spectrin-associated cytoskeleton [ISS]
- tight junction [IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human MAP kinase interactome.
Mitogen-activated protein kinase (MAPK) pathways form the backbone of signal transduction in the mammalian cell. Here we applied a systematic experimental and computational approach to map 2,269 interactions between human MAPK-related proteins and other cellular machinery and to assemble these data into functional modules. Multiple lines of evidence including conservation with yeast supported a core network of 641 interactions. Using ... [more]
Nat. Methods Oct. 01, 2010; 7(10);801-5 [Pubmed: 20936779]
Throughput
- High Throughput
Curated By
- BioGRID