BAIT
MAP4K4
FLH21957, HEL-S-31, HGK, MEKKK4, NIK
mitogen-activated protein kinase kinase kinase kinase 4
GO Process (4)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
KIF5A
D12S1889, MY050, NKHC, SPG10
kinesin family member 5A
GO Process (9)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- ATP catabolic process [IBA]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- axon guidance [IBA]
- blood coagulation [TAS]
- cytoskeleton-dependent intracellular transport [IBA]
- metabolic process [IBA, TAS]
- microtubule-based movement [IBA, TAS]
- protein localization [IBA]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human MAP kinase interactome.
Mitogen-activated protein kinase (MAPK) pathways form the backbone of signal transduction in the mammalian cell. Here we applied a systematic experimental and computational approach to map 2,269 interactions between human MAPK-related proteins and other cellular machinery and to assemble these data into functional modules. Multiple lines of evidence including conservation with yeast supported a core network of 641 interactions. Using ... [more]
Nat. Methods Oct. 01, 2010; 7(10);801-5 [Pubmed: 20936779]
Throughput
- High Throughput
Curated By
- BioGRID