BAIT

FOS

AP-1, C-FOS, p55

FBJ murine osteosarcoma viral oncogene homolog

Cell Cycle - Senescence Project

Human Papilloma Virus (HPV) Project

GO Process (23)

GO Function (4)

GO Component (2)

Gene Ontology Biological Process

DNA methylation [TAS]

Fc-epsilon receptor signaling pathway [TAS]

MyD88-dependent toll-like receptor signaling pathway [TAS]

MyD88-independent toll-like receptor signaling pathway [TAS]

SMAD protein signal transduction [IDA]

TRIF-dependent toll-like receptor signaling pathway [TAS]

cellular response to reactive oxygen species [IDA]

inflammatory response [TAS]

innate immune response [TAS]

positive regulation of transcription, DNA-templated [IDA]

regulation of sequence-specific DNA binding transcription factor activity [TAS]

regulation of transcription from RNA polymerase II promoter [TAS]

stress-activated MAPK cascade [TAS]

toll-like receptor 10 signaling pathway [TAS]

toll-like receptor 2 signaling pathway [TAS]

toll-like receptor 3 signaling pathway [TAS]

toll-like receptor 4 signaling pathway [TAS]

toll-like receptor 5 signaling pathway [TAS]

toll-like receptor 9 signaling pathway [TAS]

toll-like receptor TLR1:TLR2 signaling pathway [TAS]

toll-like receptor TLR6:TLR2 signaling pathway [TAS]

toll-like receptor signaling pathway [TAS]

transforming growth factor beta receptor signaling pathway [IDA]

Gene Ontology Molecular Function

R-SMAD binding [IPI]
protein binding [IPI]
sequence-specific DNA binding transcription factor activity [IDA]
transcription regulatory region DNA binding [IDA]

Gene Ontology Cellular Component

nucleoplasm [IDA, TAS]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

KDM2A

CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA

lysine (K)-specific demethylase 2A

GO Process (2)

GO Function (0)

GO Component (2)

Gene Ontology Biological Process

double-strand break repair via nonhomologous end joining [IMP]

histone H3-K36 demethylation [IMP]

Gene Ontology Cellular Component

nucleolus [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A human MAP kinase interactome.

Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T

Mitogen-activated protein kinase (MAPK) pathways form the backbone of signal transduction in the mammalian cell. Here we applied a systematic experimental and computational approach to map 2,269 interactions between human MAPK-related proteins and other cellular machinery and to assemble these data into functional modules. Multiple lines of evidence including conservation with yeast supported a core network of 641 interactions. Using ... [more]

Nat. Methods Oct. 01, 2010; 7(10);801-5 [Pubmed: 20936779]

Throughput

High Throughput

Curated By

BioGRID