BAIT

UBE2I

C358B7.1, P18, UBC9, LA16c-358B7.1

ubiquitin-conjugating enzyme E2I

GO Process (8)

GO Function (9)

GO Component (6)

Gene Ontology Biological Process

cellular protein metabolic process [TAS]

cellular protein modification process [TAS]

negative regulation of transcription from RNA polymerase II promoter [IMP]

negative regulation of transcription, DNA-templated [IDA]

post-translational protein modification [TAS]

protein sumoylation [IDA, TAS]

protein ubiquitination [IBA]

ubiquitin-dependent protein catabolic process [TAS]

Gene Ontology Molecular Function

RING-like zinc finger domain binding [IPI]
SUMO transferase activity [IDA]
enzyme binding [IPI]
poly(A) RNA binding [IDA]
protein binding [IPI]
transcription factor binding [IPI]
ubiquitin protein ligase activity [IBA]
ubiquitin protein ligase binding [IBA]
ubiquitin-protein transferase activity [TAS]

Gene Ontology Cellular Component

cytoplasm [IDA]

nucleoplasm [TAS]

synaptonemal complex [TAS]

transferase complex [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

SETX

ALS4, AOA2, SCAR1, bA479K20.2, RP11-203M2.2

senataxin

Fanconi Anemia Project

GO Process (19)

GO Function (4)

GO Component (6)

Gene Ontology Biological Process

DNA duplex unwinding [TAS]

MAPK cascade [IDA]

RNA processing [TAS]

cellular response to DNA damage stimulus [IDA]

cellular response to fibroblast growth factor stimulus [IDA]

cellular response to hydrogen peroxide [IDA]

cellular response to oxidative stress [IDA]

cellular response to retinoic acid [IDA]

double-strand break repair [IDA]

fibroblast growth factor receptor signaling pathway [IDA]

mRNA splice site selection [IMP]

negative regulation of apoptotic process [IDA]

positive regulation of DNA-templated transcription, initiation [IMP]

positive regulation of DNA-templated transcription, termination [IMP]

positive regulation of RNA splicing [IMP]

positive regulation of neuron projection development [IDA]

positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled [IMP]

positive regulation of transcription from RNA polymerase II promoter [IMP]

protein kinase B signaling [IDA]

Gene Ontology Molecular Function

DNA binding [IC]
DNA helicase activity [TAS]
protein binding [IPI]
transcription termination site sequence-specific DNA binding [IDA]

Gene Ontology Cellular Component

cytoplasm [IDA]

growth cone [IDA]

nuclear chromosome [IDA]

nucleoplasm [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A human MAP kinase interactome.

Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T

Mitogen-activated protein kinase (MAPK) pathways form the backbone of signal transduction in the mammalian cell. Here we applied a systematic experimental and computational approach to map 2,269 interactions between human MAPK-related proteins and other cellular machinery and to assemble these data into functional modules. Multiple lines of evidence including conservation with yeast supported a core network of 641 interactions. Using ... [more]

Nat. Methods Oct. 01, 2010; 7(10);801-5 [Pubmed: 20936779]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
SETX UBE2I	Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.	Bennett CL (2013)	High	-	BioGRID	-

Curated By

BioGRID